Methods guide
Genome-wide association studies
A GWAS compares genetic variants across many people to identify regions associated with a disease or measurable trait.
The central question
Where in the genome is variation associated with a trait?
- 01
Measure genetic variation across the genome
- 02
Test each variant for statistical association
- 03
Correct for ancestry, study design and multiple testing
- 04
Replicate findings and interpret associated regions