Lupus genetics

Genes associated with lupus

Gene profiles connect robust SLE association signals to their likely causal variants, biological effects and supporting evidence.

Evidence library

SLE-associated genes

InsideGen distinguishes evidence for association from evidence about causal variants and biological mechanism. More gene profiles will be added as their evidence is reviewed.

Gene profileTwo independent signals

TYK2

Tyrosine kinase 2

Strong, consistently replicated evidence for association with SLE.View TYK2 evidence →

Gene profileCross-ancestry evidence

ITGAM

Integrin subunit alpha M · CD11b

Robust association with SLE across European, African American and Hispanic Amerindian ancestries.View ITGAM evidence →