Systemic lupus erythematosus

Understanding the genetic signals behind lupus.

Explore what is known, how the evidence was established, why it matters and where uncertainty remains.

TypeComplex autoimmune diseaseEvidenceHuman genetics researchResource statusActive and expanding

Inside this resource

Explore lupus from seven perspectives

Begin with an accessible introduction or move directly into detailed genetic evidence and open research questions.

A clear introduction to SLE, its symptoms and the immune system.

Heritability, genetic associations and what they reveal about susceptibility.

Genes associated with lupus, the supporting evidence and relevant variants.

Diseases that share genetic effects and biological pathways with lupus.

An accessible, step-by-step route through lupus and its genetics.

Groups, consortia, patient organisations, meetings and resources.

Important hypotheses, current evidence and what could resolve them.

Prefer a different route?