Lupus resource
The genetics of lupus
Lupus is genetically complex. Many variants contribute small effects to susceptibility, alongside environmental, hormonal and other biological influences.
What this section covers
Evidence, explanation and context
- Family and twin studies provide evidence for heritability.
- Genome-wide association studies have identified many associated regions.
- Fine-mapping and functional studies help connect those regions to variants, genes and mechanisms.
Editorial noteEvidence strength and uncertainty should be stated for every association.