Find genetic signals
Large-scale association studies help identify the regions of the genome linked to lupus susceptibility.
Lupus genetics · Immunity · Open science
Reading the genetic signals behind lupus.
InsideGen brings together research, data and progress in the genetics of systemic lupus erythematosus—turning complex evidence into knowledge that can be shared.
Research led atKing's College LondonFocused onSLE genetics
From association to mechanism
100+genetic loci implicated
Our purpose
Complex disease needs a connected view.
Genes do not act in isolation. Our work combines evidence across the genome and immune system to clarify why lupus develops, why it varies between people and where future research should look next.
How we work
From association to understanding
Connect genes to biology
We integrate genetic evidence with functional data to understand the immune pathways driving disease.
Share evidence
Results, research context and data resources are made accessible to scientists and the wider community.
Research for everyone
Different questions.
One shared evidence base.
Whether you live with lupus, study autoimmune disease or simply want to understand the science, start with the route that makes sense for you.
Featured publication
Genetic association analyses implicate regulation of innate and adaptive immunity in SLE.
Bentham J*, Morris DL* et al. Nature Genetics (2015)
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